trypanosoma brucei — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4S0590	Columbin		Phospholipase , COX , Parasite
	1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.		Phospholipase , COX , Parasite
T27135	DDD85646	DDD 85646,DDD-85646	Parasite
	DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.		Parasite
T63059	CRK12-IN-1		Antibiotic
	CRK12-IN-1 is a potent CRK12 inhibitor.CRK12-IN-1 has insecticidal activity, with inhibitory effects on Trypanosoma brucei (T.b. brucei) and Trypanosoma congolense (T. congolense) with EC50s of 1.3 and 18 nM, respectivel...		Antibiotic
T3792	Ajugol	Leonuride	Parasite
	Ajugol (Leonuride) shows some trypanocidal potential against Trypanosoma brucei rhodesiense (IC50 values 29.3–73.0 ug/ml).		Parasite
T10340	Antitrypanosomal agent 2		Parasite
	Antitrypanosomal agent 2 shows potent and specific antiparasite activities against Trypanosoma brucei.		Parasite
T23973	DDD100097	DDD 100097,DDD-100097	Others
	DDD100097 is a potent N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.		Others
T77551	6'-hydroxydihydrocinchonidine		Antibiotic , Drug Metabolite
	6'-hydroxydihydrocinchonidine is a metabolite of quinine, with antimicrobial and antitumor activity, and inhibitory effect on Trypanosoma brucei and Streptococcus pneumoniae.		Antibiotic , Drug Metabolite
T77645	JC-229		TRP/TRPV Channel
	JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).		TRP/TRPV Channel
T2112	Fexinidazole	HOE 239	Others , Parasite
	Fexinidazole (HOE 239) is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologica...		Others , Parasite
T2S1792	Lycobetaine	Ungeremine	Antibacterial
	1. Lycobetaine (Ungeremine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Lycobetaine have strong antibacterial activity against Flavobacterium columnare . 3. Lycobetaine effectively...		Antibacterial
T23132	Pentamidine dihydrochloride	MP-601205 dihydrochloride	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi...
T69764	NPD-008
	NPD-008 is an inhibitor of trypanosoma brucei phosphodiesterase B1 (TbrPDEB1).
T69765	NPD-039
	NPD-039 is an inhibitor of trypanosoma brucei phosphodiesterase B1 (TbrPDEB1).
TN2485	1,2-Dihydrotanshinone	1,2-Dihydrotanshinquinone	Antifection
	1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.		Antifection
T13223	Tuberculosis inhibitor 1		Others
	Tuberculosis inhibitor 1 is a potent and non-cytotoxic inhibitor of trypanosoma brucei growth (EC50: 5 nM).		Others
TN3220	7',8'-Dihydroobolactone		Antifection
	7',8'-Dihydroobolactone can inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.		Antifection
T6769	Elaiophylin	Efomycin E,Gopalamicin,Salbomycin,Azalomycin B	Others , Autophagy
	Elaiophylin (Salbomycin) shows antiprotozoal activity against Plasmodium falciparum K1a and Trypanosoma brucei brucei GUTat 3.1 strains with IC50 of 0.36 μM and 0.45 μM, respectively.		Others , Autophagy
T12286	Obtusifoliol		Others
	Obtusifoliol is a specific inhibitor of CYP51(Trypanosoma brucei (TB) and human CYP51 with Kd values of 1.2 µM and 1.4 µM, respectively).		Others
T69313	Ascofuranone
	Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODH.
T61912	TbPTR1 inhibitor 1
	TbPTR1 inhibitor 1 (compound 5d) is an effective inhibitor of kinetochore pteridine reductase 1 (PTR1). The IC50 of TbPTR1 inhibitor 1 inhibits Trypanosoma brucei PTR1 (TbPTR1) is <0.1 nM, EC50 of TbPTR1 inhibitor 1 inhi...